Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia
نویسندگان
چکیده
منابع مشابه
Oxidative Stress in Schizophrenia
Increasing evidence indicates that oxidative damage exists in schizophrenia. Available literature about possible mechanisms of oxidative stress induction was reviewed. Furthermore, possibilities of measuring biomarkers of schizophrenia outside the central nervous system compartment, their specificity for different types of schizophrenia and potential therapeutic strategies to prevent oxidative ...
متن کاملOxidative Stress and Schizophrenia
Many studies show that oxidative stress is a pathophysiological mechanism of schizophrenia. Elevated oxidative stress levels and the damage to the antioxidant defense system can observed in early schizophrenia. High oxidation levels damage lipids, proteins, nucleic acids and other tissues. Antioxidant defense system imbalance has been observed in both neuroleptic-naïve first-episode schizophren...
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We aimed to investigate oxidative stress biomarkers in a cross-sectional pilot study of 50 participants with sporadic ALS (SALS) compared to 46 control subjects. We measured urinary 8-oxodeoxyguanosine (8-oxodG), urinary 15-F(2t)-isoprostane (IsoP), and plasma protein carbonyl by ELISA methods. We also determined if ELISA measurement of 8-oxodG could be validated against measures from high-pres...
متن کاملOxidative stress and superoxide dismutase in schizophrenia.
Oxyradicals are chemical species with an unpaired electron in one of their orbits. Production of oxyradicals occurs throughout the body during cellular metabolism [l]. A complex antioxidant system exists to regulate levels of oxyradicals as excessive production or ineffective removal can result in cellular damage. The antioxidant enzymes present indude superoxide dismutase (SOD), glutathione pg...
متن کاملMeta-analysis of oxidative stress in schizophrenia.
BACKGROUND Schizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psychosis. METHODS We identified articles by searching PubMed, PsychInfo, and In...
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ژورنال
عنوان ژورنال: Clinical Neurophysiology
سال: 2013
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2013.05.021